Bi-specific extracellular matrix binding peptides and methods of use thereof
AssigneeUniversity of Tartu
InventorsTambet Teesalu, Prakash Lingasamy
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Abstract
Disclosed are compositions, compounds, and methods relating to peptides that can target and home to cancer, tumors, and extracellular matrix. This is based on the discovery of peptides that can specifically bind to fibronectin extra domain B (FN-EDB), tenascin-C C domain (TNC-C), or both.
Claims24
An isolated peptide comprising PPRRGLIKLKTS (SEQ ID NO:1) or PPRRGLIKLKTSSNTKENSVVASLRP (SEQ ID NO:2).
An isolated peptide comprising an amino acid sequence, wherein the amino acid sequence consists of PPRRGLIKLKTS (SEQ ID NO:1) or of a variant of SEQ ID NO:1 with one, two, three, four, five, six, seven, or eight amino acid substitutions, wherein position 6 of SEQ ID NO:1 remains leucine and position 11 of SEQ ID NO:1 remains threonine, and wherein all of the amino acid substitutions are conservative amino acid substitutions.
An isolated peptide comprising any one of SEQ ID NOs:1, 2, 54, 56-59, or 61-65, wherein the isolated peptide selectively binds to fibronectin extra domain B (FN-EDB), tenascin-C C domain (TNC-C), or both FN-EDB and TNC-C.
Dependencies are inferred from the claim text.