Compositions of hybrid supported lipid bilayers and methods for producing

A hybrid supported lipid bilayer (HSLB) comprising:

• a solid surface;
• a lipid bilayer supported on the solid surface, the lipid bilayer comprising a phospholipid and a copolymer, wherein the copolymer is present in the lipid bilayer in an amount of 15 mol. % to 50 mol. % relative to a combined amount of the phospholipid and the copolymer;
• and
• a plurality of copies of a membrane protein, wherein:
• the plurality of copies of the membrane protein is functional, properly oriented within the lipid bilayer, and mobile within the lipid bilayer;
• and
• at least 82% of the plurality of copies of the membrane protein have a native physiological orientation relative to the solid surface;
• wherein at least one of condition (I) and condition (II) is satisfied:
• (I) the HSLB has a membrane protein mobile fraction of at least 0.4;
• and
• (II) the HSLB has a membrane protein diffusivity in a range of 0.08 μm2/s to 0.28 μm2/s.