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US 12,583,871 B2Granted
PRMT5 inhibitors
AssigneeMerck Sharp & Dohme Corp.
InventorsMichelle Machacek, Michael D. Altman, Shuhei Kawamura, David L Sloman, David J. Witter, Craig R. Gibeau
Life of this patent
Estimating the term…
Abstract
The present invention provides a compound selected from: and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds disclosed herein, pharmaceutical compositions comprising compounds disclosed herein, and methods of using these compounds to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.
Claims16
A compound selected from:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.