Anti-liferative agents comprising substituted benzo[e]pyrido[1,2-a][1,4]diazepines

A compound of formula (XVI):

• or a pharmaceutically acceptable salt thereof,
• wherein:
• (i) R5 is H;
• and
• R6 is OH or OC1-6 alkyl;
• or
• (ii) R5 and R6, taken together with the N atom and C atom to which they are attached, form N═C;
• L is C1-12 alkylene-;
• Y5 is CH or N;
• q is 1;
• Y1 is CH or N;
• Y2 is CH or N;
• R19 is H or (CH2)tNR20R21;
• t is 0, 1, 2, 3, 4, 5, or 6;
• R20 is H or C1-6 alkyl;
• R21 is H or C1-6 alkyl;
• p is 1;
• Z1 is —NH—, —N(CH3)—, —O—, or —S—;
• Z2 is CH or N;
• R22 is (CH2)jC(O)OH, (CH2)jC(O)OC1-6 alkyl, (CH2)jNR11R12, or C(O)NHR24;
• R24 is phenyl, wherein the phenyl is substituted with one (CH2)jR18 substituent;
• j is 0, 1, 2, 3, 4, 5, or 6;
• R18 is H, C(O)OR11, or NR11R12;
• R11 is H or C1-6 alkyl;
• and
• R12 is H or C1-6 alkyl;
• with the proviso that at least one of Y1 and Y2 is CH.