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US 12,583,854 B2Granted
KRAS G12C inhibitors and methods of using the same
AssigneeAmgen Inc.
InventorsJian Chen, Nuria A. Tamayo, Longbin Liu, Hui-Ling Wang, Brian Alan Lanman, Ryan Paul Wurz, Youngsook Shin, Victor J. Cee
Life of this patent
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Abstract
Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
Claims35
A compound of Formula (Ia):
- or a pharmaceutically acceptable salt thereof;
- wherein
- R2 is aryl, wherein the aryl is substituted with one or more groups independently selected from halo, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, —CF3, —OCF3, —NO2, —CN, —NC, —OH, alkoxy, amino, —CO2H, —CO2C1-C6alkyl, —OCOC1-C6alkyl, C3-C10cycloalkyl, C3-C10heterocycloalkyl, C5-C10aryl, and C5-C10heteroaryl;
- R3 is halo;
- R4 is
- and
- R8 is
4 more elements
A compound, wherein the compound is
Dependencies are inferred from the claim text.