Back to results
US 12,583,850 B2Granted
Small molecule antiviral drug treatment for human papillomavirus infections
AssigneesThe Trustees of Indiana University, Kovina Therapeutics, Inc.
InventorsElliot J. Androphy, Samy Meroueh, Anne Rietz, Zhijan Lu
Life of this patent
Estimating the term…
Abstract
Compositions and methods are provided for treating HPV infections including pre-malignant and cancers. Compounds that specifically bind to the HPV E6 protein and inactivate the protein are disclosed.
Claims30
A compound of Formula III:
- or a pharmaceutically acceptable salt thereof,
- wherein:
- Y is CH or N;
- X3 is CH or N;
- W is —(CH2)n or —CH═CH—;
- R31 is —CH═CH2, —CR51═CH2, —CH═CHCH2N(CH3)2, —CH═CHCH3, —CH2(halo), or —CH3, wherein R51 is H or halo;
- R35 is H or halo;
- R36 is H, halo, —OCH3, —OCH2CH3, —OCH2CH2OCH3, —OCH2CH2—N-pyrrolidine, or —CONHCH3;
- R40 is H, —OCH3, —OCH2CH3, or —OCH2CH2OCH3;
- R41 is H or —C1-C4 alkyl;
- R42 is H, —CN, or —C1-C4 alkyl, or R41 and R42 together with the atoms to which they are attached form a 3- to 6-membered heterocycloalkyl ring;
- and
- n is 2, 3, or 4.
10 more elements
Dependencies are inferred from the claim text.