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US 12,583,848 B2Granted
Isoxazole-3-carboxamide derivatives and their use for treatment of diseases caused by virus infection
AssigneesCollaborations Pharmaceuticals, Inc., Universitätsklinikum Jena
InventorsVadim Makarov, Michaela Schmidtke, Sean Ekins
Life of this patent
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Abstract
Isoxazole-3-carboxamide derivatives and their use in treating viral infections and diseases, such as diseases caused by viruses of the Picornaviridae family of viruses (e.g., rhinoviruses, enteroviruses, and coxsackieviruses) is described. The derivatives have good efficacy against a range of viruses, including pleconaril-resistant viral strains, and have low induction of cytochrome P4503A4 (CYP3A4).
Claims20
A compound of the formula (I)
- wherein:
- R1 and R2 are independently selected from H, a saturated or unsaturated, linear or branched C1-C8alkyl, and benzyl, or wherein R1 and R2 together are C3-Ca alkylene;
- and
- R3 and R4 are independently selected from H, fluoro (F), chloro (CI), methyl (Me), methoxy (OMe), trifluoromethyl (CF3), and nitro (NO2).
1 more element
Dependencies are inferred from the claim text.