Fluorinated pyrimidine compound and method for producing same

A method for producing a fluorinated pyrimidine compound, comprising:

• reacting a fluoroisobutylene derivative represented by the following general formula (2) with a compound represented by the following general formula (3a) or a salt thereof to obtain a fluorinated pyrimidine compound represented by the following general formula (1a), or
• reacting a fluoroisobutylene derivative represented by the following general formula (2) with a compound represented by the following general formula (3b) or a salt thereof to obtain a fluorinated pyrimidine compound represented by the following general formula (1b):
• wherein
• R1 represents a hydrocarbon group having 1 to 12 carbon atoms,
• R2 represents a halogen atom, a hydrocarbon group having 1 to 10 carbon atoms, —CnF2n+1 where n is an integer of 1 to 10, a nitro group, a boronic acid group, a cyano group, —OA1, —OlSOmA1 where l is an integer of 0 to 1 and m is an integer of 0 to 3, —NA1A2, —OlCOOA1 where l is an integer of 0 to 1, or —OlCONA1A2 where l is an integer of 0 to 1, A1 and A2 each independently represent a hydrogen atom or a hydrocarbon group having 1 to 10 carbon atoms, A1 and A2 may be bonded to form a ring structure, and when a plurality of R2 is present, the plurality of R2 is the same or different from each other, and a ring Z is a 5-membered aromatic heterocyclic ring containing one oxygen atom and one or more nitrogen atoms.

A method for producing a fluorinated pyrimidine compound, comprising:

• reacting a fluoroisobutane derivative represented by the following general formula (4) with a compound represented by the following general formula (3a) or a salt thereof to obtain a fluorinated pyrimidine compound represented by the following general formula (1a), or
• reacting a fluoroisobutane derivative represented by the following general formula (4) with a compound represented by the following general formula (3b) or a salt thereof to obtain a fluorinated pyrimidine compound represented by the following general formula (1b):
• wherein
• R1 represents a hydrocarbon group having 1 to 12 carbon atoms,
• R2 represents a halogen atom, a hydrocarbon group having 1 to 10 carbon atoms, —CnF2n+1 where n is an integer of 1 to 10, a nitro group, a boronic acid group, a cyano group, —OA1, —OlSOmA1 where l is an integer of 0 to 1 and m is an integer of 0 to 3, —NA1A2, —OlCOOA1 where l is an integer of 0 to 1, or —OlCONA1A2 where l is an integer of 0 to 1, A1 and A2 each independently represent a hydrogen atom or a hydrocarbon group having 1 to 10 carbon atoms, A1 and A2 may be bonded to form a ring structure, and when a plurality of R2 is present, the plurality of R2 is the same or different from each other, a ring Z is a 5-membered aromatic heterocyclic ring containing one oxygen atom and one or more nitrogen atoms, and
• X represents a halogen atom, a cyano group, —OA3, —NA3A4, —OCOOA3, —OCONA3A4, or —OlSOmA5 where l is an integer of 0 to 1 and m is an integer of 0 to 3, A3 and A4 each independently represent a hydrocarbon group having 1 to 10 carbon atoms, A3 and A4 may be bonded to form a ring structure, and A5 represents a hydrogen atom or a hydrocarbon group having 1 to 10 carbon atoms.