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US 12,583,841 B2Granted
Tetrahydropyrrolocyclic compound and application thereof
AssigneeBreakthrough Pharmaceuticals Inc.
InventorsWei Wei, Peng Li, Na Gao, Haiying He, Jian Li, Shuhui Chen
Life of this patent
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Abstract
A tetrahydropyrrolocyclic compound as represented by formula (I), a pharmaceutically acceptable salt thereof, and an application thereof in preparation of a drug for treating a disease related to a selective orexin-2 (OX-2) receptor antagonist, wherein the related disease is selected from insomnia and depression.
Claims11
A compound represented by formula (I) or a pharmaceutically acceptable salt thereof:
- wherein
- each R1 is independently selected from halogen, cyano, C1-3alkyl and C1-3alkoxy, and the C1-3alkyl and C1-3alkoxy are each independently and optionally substituted by 1, 2 or 3 halogen atoms;
- each R2 is independently selected from halogen, cyano, C1-3alkyl and C1-3alkoxy, and the C1-3alkyl and C1-3alkoxy are each independently and optionally substituted by 1, 2 or 3 halogen atoms;
- R3 is selected from H, C1-3alkyl and C3-6cycloalkyl;
- m and n are each independently selected from 0, 1, 2 and 3;
- ring A is selected from
- ring B is selected from
4 more elements
A compound represented by the following formula or a pharmaceutically acceptable salt thereof, wherein the compound is selected from:
Dependencies are inferred from the claim text.