PD-L1 antagonist compound

A compound of formula (I) or a pharmaceutically acceptable salt thereof,

• wherein L1 is selected from —CRARB— and —C(O)—;
• L2, L3 is selected from —(CRCRD)p, —(CRCRD)p—NRa—(CRCRD)q—, —(CRCRD)p—O—(CRCRD)q— and —C(O)—;
• W1, W2 each independently represent CRL or N;
• R1 each independently represent hydrogen, halogen, nitro, cyano or —NRaRb or C1-C6 alkyl, C3-C6 cycloalkyl, —O(C1-C6 alkyl), —O(C0-C6 alkylene)(C3-C6 cycloalkyl) or —O(C0-C6 alkylene)(3-6 membered heterocycloalkyl) substituted with 0, 1, 2 or 3 substituents;
• wherein the substituents are selected from —ORa, cyano, oxo, halogen, C1-C6 alkyl, —(C1-C6 alkylene)ORa, cyano C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, —C(O)Ra, —(C1-C6 alkylene)C(O)Ra, —C(O)ORa, —(C1-C6 alkyl)C(O)ORa, —NRaRb, —(C1-C6 alkylene)NRaRb, —C(O)NRaRb, —SO2Ra, —C(O)NRaSO2Rb and —NRaC(O)Rb, wherein the 3-6 membered heterocycloalkyl contain 1, 2 or 3 heteroatoms selected from N, O and S;
• R2 and R3 each independently represent hydrogen, halogen, nitro, cyano, —NRaRb, —SO2Ra, —S(O)Ra, —P(O)RaRb, C1-C6 alkyl, —O(C1-C6 alkyl), —O(C3-C6 cycloalkyl), halo(C1-C6 alkyl) or C3-C6 cycloalkyl;
• R4 and R5 each independently represent halogen, nitro, cyano, —NRaRb, —SO2Ra, —S(O)Ra, —P(O)RaRb, C1-C6 alkyl, —O(C1-C6 alkyl), —O(C3-C6 cycloalkyl), halo(C1-C6 alkyl) or C3-C6 cycloalkyl;
• Cy represents phenylene or six-membered heteroaryl substituted by 0, 1, 2 or 3 R6, wherein the six-membered heteroaryl may optionally contain 1 or 2 nitrogen atoms;
• wherein the R6 represents hydrogen, halogen, nitro, cyano, —NRaRb, —SO2Ra, —S(O)Ra or —P(O)RaRb or C1-C6 alkyl, C3-C6 cycloalkyl, —O(C1-C6 alkyl), —O(C0-C6 alkylene)(C5-C10 aryl), —O(C0-C6 alkylene)(5-10 membered heteroaryl), —O(C0-C6 alkylene)(C3-C6 cycloalkyl) or —O(C0-C6 alkylene)(3-6 membered heterocycloalkyl) substituted with 0, 1, 2 or 3 substituents;
• wherein the substituents are selected from —ORa, cyano, oxo, halogen, C1-C6 alkyl, —(C1-C6 alkylene)ORa, cyano C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, —C(O)Ra, —(C1-C6 alkylene)C(O)Ra, —C(O)ORa, —(C1-C6 alkylene)C(O)ORa, —NRaRb, —(C1-C6 alkylene)NRaRb, —C(O)NRaRb, —SO2Ra, —C(O)NRaSO2Rb or —NRaC(O)Rb, wherein the six-membered heteroaryl contains 1, 2, 3 or 4 heteroatoms independently selected from N, O and S, and the 3-6 membered heterocycloalkyl contain 1, 2 or 3 heteroatoms selected from N, O and S;
• wherein RL represents hydrogen, C1-C6 alkyl, —O(C1-C6 alkyl), —O(C3-C6 cycloalkyl), halogen, nitro, cyano, —NRaRb, halo(C1-C6 alkyl) or C3-C6 cycloalkyl;
• T, A each independently represent —(C1-C6 alkyl), —(C0-C6 alkylene)-(C3-C12 cycloalkyl), —(C0-C6 alkylene)-(3-12 membered heterocycloalkyl), —(C0-C6 alkylene)-(C6-C10 aryl) or —(C0-C6 alkylene)-(5-10 membered heteroaryl) substituted with 0, 1, 2 or 3 substituents, wherein the substituents are selected from:
• cyano, oxo, halogen, C1-C6 alkyl, —(C0-C6 alkylene)ORa, cyano C1-C6 alkyl, halo(C1-C6 alkyl), C3-C8 cycloalkyl, —(C0-C6 alkylene)C(O)Ra, —(C0-C6 alkylene)C(O)ORa, —(C0-C6 alkenyl)C(O)ORa, —(C0-C6 alkylene)NRaRb, —C(O)NRaRb, —NRaSO2Rb, —C(O)NRaSO2Rb and —NRaC(O)Rb, wherein the 3-12 membered heterocycle is a heteroaryl or a heterocycloalkyl which contains 1, 2 or 3 heteroatoms selected from N, O and S, and the 5-10 membered heteroaryl contains 1, 2, 3 or 4 heteroatoms independently selected from N, O and S;
• wherein RA, RB each independently represent hydrogen, C1-C6 alkyl, —(C0-C3 alkylene)(C3-C12 cycloalkyl), —(C0-C3 alkylene)(3-12 membered heterocycloalkyl), halo(C1-C6 alkyl) or halogen, or RA and RB together with their co-attached carbon atoms form a 3-6 membered ring, wherein the 3-12 membered heterocycle is a heteroaryl or a heterocycloalkyl which contains 1, 2 or 3 heteroatoms selected from N, O and S;
• and the 3-6 membered ring contains a carbon atom and a heteroatom selected from N, O and S;
• RC, RD each independently represent:
• hydrogen, C1-C6 alkyl, —(C0-C3 alkylene)(C3-C12 cycloalkyl), —(C0-C3 alkylene)(3-12 membered heterocycloalkyl), halo(C1-C6 alkyl) or halogen, or RC and RD together with their co-attached carbon atom form a 3-6 membered ring, wherein the 3-12 membered heterocycle is a heteroaryl or a heterocycloalkyl which contains 1, 2 or 3 heteroatoms selected from N, O and S, and the 3-6 membered ring contains a carbon atom and a heteroatom selected from N, O and S;
• Ra, Rb each independently represent hydrogen, C1-C6 alkyl, halo(C1-C6 alkyl), —(C0-C6 alkylene)OH, —(C0-C3 alkylene)(C3-C12 cycloalkyl), —(C0-C3 alkylene)(3-12 membered heterocycloalkyl), —(C0-C3 alkylene)(C6-C10 aryl), —(C0-C3 alkylene)(5-10 membered heteroaryl) or halo(C1-C6 alkyl), or Ra and Rb together with their co-attached atom form a 3-6 membered ring, wherein the 3-12 membered heterocycle is a heteroaryl or a heterocycloalkyl which contains 1, 2 or 3 heteroatoms selected from N, O and S, the 5-10 membered heteroaryl contains 1, 2, 3 or 4 heteroatoms independently selected from N, O and S, and the 3-6 membered ring contains a carbon atom and a heteroatom selected from N, O and S;
• wherein m, o each independently represent 0, 1 or 2;
• and
• wherein p, q each independently represent 0, 1, 2 or 3.