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US 12,583,836 B2Granted
Sulphonamide compounds
AssigneeAnaxis Pharma Pty Ltd
InventorsJean-Marc Daniel Garnier, Martin Brzozowski, John Thomas Feutrill, Guillaume Laurent Lessene, Christopher Gardner, Peter Edward Czabotar, Angus Cowan, Katherine Davies, Pooja Sharma, Carole Annie Schuster-Klein, Christophe Poitevin
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Abstract
This invention relates to compounds of formula (I) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compounds of formula (I) to treat necroptosis and/or inhibit MLKL.
Claims22
A compound of formula (I)
- wherein
- Q1 and Q2 are selected from N and NR1, wherein when Q1 is N, Q2 is NR1 and when Q2 is N, Q1 is NR1;
- R1 and R3 are independently selected from H and an optionally substituted C1-6-alkyl;
- R2 is an optionally substituted C1-6-alkyl, an optionally substituted aryl or an optionally substituted heterocyclyl;
- X is selected from optionally substituted C1-6alkyl, optionally substituted haloC1-6alkyl, optionally substituted C2-6alkynyl, optionally substituted cycloalkyl, optionally substituted halocycloalkyl, optionally substituted aryl, optionally substituted alkylaryl, optionally substituted C1-6alkylcycloalkyl and optionally substituted amino;
- Y and Z are independently selected from H, R4, —OR4, —NR4R5,
- wherein at least one of Y and Z is H;
- R4 is selected from optionally substituted C1-6alkyl, optionally substituted aryl, optionally substituted C1-6alkylaryl, optionally substituted heterocyclyl, optionally substituted C1-6alkylheterocyclyl, optionally substituted cycloalkyl, optionally substituted C1-6alkylC3-10cycloalkyl, optionally substituted C3-10cycloalkylaryl, optionally substituted C3-10cycloalkylheterocyclyl, optionally substituted C3-10cycloalkylC3-10cycloalkyl, optionally substituted 3-6 membered non-aromatic heterocyclyl-aryl, optionally substituted 3-6 membered non-aromatic heterocyclylC3-10cycloalkyl and optionally substituted 3-6 membered non-aromatic heterocyclyl-3-10 membered heterocyclyl;
- and
- R5 is H or optionally substituted C1-6alkyl,
- or a pharmaceutically acceptable salt, solvate, tautomer, N-oxide, stereoisomer and/or prodrug thereof.
8 more elements
Dependencies are inferred from the claim text.