Method of treating bacterial infections and pharmaceutical composition for treating bacterial infections
AssigneeInstitut National De Recherche Pour L'agriculture, L'alimentation Et L'environnement
InventorsNalini Rama Rao, Seav-Ly Tran
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Abstract
The invention relates to a compound having the general formula (I), or one of the pharmaceutically acceptable salts thereof, for it use as a medicament, in particular for treating a bacterial infection in a subject: In particular, this compound is capable of inhibiting the Mfd activity of bacteria.
Claims14
A method of treating a bacterial infection in a subject, comprising administering to the subject a therapeutically-effective amount of a compound having the general formula (I):
- wherein
- m is an integer between 0 and 2,
- n is equal to 0 or 1,
- is equal to 0 or 1,
- p is an integer between 0 and 2,
- p′ is an integer between 0 and 2,
- either the double line represents a single bond and
- X is selected from the group consisting of an oxygen atom, CH2, NH, N—R5 and —NCO—R5, wherein R5 represents a linear, branched and/or cyclic, saturated or unsaturated, hydrocarbon-based radical, optionally substituted, optionally comprising one or several heteroatoms and/or one or more groups containing one or more heteroatoms,
- and Y represents a methylene group, a carbonyl group, a thiocarbonyl group or a C═N—R9 group wherein R9 represents a hydrogen atom or an alkyl or aryl group,
- or the double line represents a double bond and X represents a nitrogen atom and Y represents a methine group,
- Z represents a covalent bond, a methylene group, a sulfonyl group, an amide group, an ester group, an ether group or a carbonyl group, provided that Z does not represent a carbonyl group when p is equal to 0,
- W represents a nitrogen atom or a C—R10 group wherein R10 represents a hydrogen atom or a linear, branched and/or cyclic, saturated or unsaturated, hydrocarbon-based radical, optionally substituted, optionally comprising one or several heteroatoms and/or one or more groups containing one or more heteroatoms,
- R1 is selected from the group consisting of a hydrogen atom, a halogen atom, a hydroxyl group, a primary amine group, a linear or branched and/or cyclic saturated or unsaturated carbon-based radical, optionally aromatic, optionally substituted, optionally comprising one or several heteroatoms and/or one or more groups containing one or more heteroatoms, a —O—R6, —NH—R6 or —NH—CO—R6 group wherein R6 represents a linear, branched and/or cyclic, saturated or unsaturated, hydrocarbon-based radical, optionally substituted, optionally comprising one or several heteroatoms and/or one or more groups containing one or more heteroatoms, and an —NR—R5 group wherein R7 and R8, which may be identical or different, each represent a linear, branched and/or cyclic, saturated or unsaturated, hydrocarbon-based radical, optionally substituted, optionally comprising one or several heteroatoms and/or one or more groups containing one or more heteroatoms,
- and R2 is selected from the group consisting of a hydrogen atom, a halogen atom, a hydroxyl group, a sulfonic acid group, a primary amine group, and a linear, branched and/or cyclic, saturated or unsaturated, carbon-based radical, optionally substituted, optionally aromatic, optionally comprising one or several heteroatoms and/or one or more groups containing one or more heteroatoms,
- or one of the pharmaceutically acceptable salts thereof.
A method of treating a bacterial infection in a subject, comprising administering to the subject a therapeutically-effective amount of a compound having the general formula (I):
- wherein
- m is an integer between 0 and 2,
- n is equal to 0 or 1
- is equal to 0 or 1,
- p is an integer between 0 and 2,
- p′ is an integer between 0 and 2,
- either the double line represents a single bond and
- X is selected from the group consisting of an oxygen atom, CH2, NH, N—R5 and —NCO—R5 wherein R5 represents a linear, branched and/or cyclic, saturated or unsaturated, hydrocarbon-based radical, optionally substituted, optionally comprising one or several heteroatoms and/or one or more groups containing one or more heteroatoms,
- and Y represents a methylene group, a carbonyl group, a thiocarbonyl group or a C═N—R2 group wherein R5 represents a hydrogen atom or an alkyl or aryl group,
- or the double line represents a double bond and X represents a nitrogen atom and Y represents a methine group,
- Z represents a covalent bond, a methylene group, a sulfonyl group, an amide group, an ester group, an ether group or a carbonyl group, provided that Z does not represent a carbonyl group when p is equal to 0,
- W represents a nitrogen atom or a C—R10 group wherein R10 represents a hydrogen atom or a linear, branched and/or cyclic, saturated or unsaturated, hydrocarbon-based radical, optionally substituted, optionally comprising one or several heteroatoms and/or one or more groups containing one or more heteroatoms,
- R1 is selected from the group consisting of a hydrogen atom, a halogen atom, a hydroxyl group, a primary amine group, a linear or branched and/or cyclic saturated or unsaturated carbon-based radical, optionally aromatic, optionally substituted, optionally comprising one or several heteroatoms and/or one or more groups containing one or more heteroatoms, a —O—R6, —NH—R6 or —NH—CO—R6 group wherein R6 represents a linear, branched and/or cyclic, saturated or unsaturated, hydrocarbon-based radical, optionally substituted, optionally comprising one or several heteroatoms and/or one or more groups containing one or more heteroatoms, and an —NR—R5 group wherein R7 and R8, which may be identical or different, each represent a linear, branched and/or cyclic, saturated or unsaturated, hydrocarbon-based radical, optionally substituted, optionally comprising one or several heteroatoms and/or one or more groups containing one or more heteroatoms, and
- R2 represents a —SO2—NR3R4 radical, wherein R3 and R4 are identical or different linear or branched alkyl groups or R3 and R4 are linked to form a ring together with the nitrogen atom to which they are attached,
- or one of the pharmaceutically acceptable salts thereof.
A method of treating a bacterial infection in a subject, comprising administering to the subject a therapeutically-effective amount of a compound having the formula (Ia):
- or one of the pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.