Enrichment of a diastereomer in Magnolan
AssigneeSymrise AG
InventorsMarcus Eh, Susanne Borchert, Marcus Betzer, Alexandre Illan, Johannes Heppekausen
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Abstract
The invention relates to a distillative process for the preparation of a diastereomer-enriched odorant mixture, and to the diastereomer-enriched odorant mixture and its use as an odorant or for the preparation of an odorant composition. Furthermore, the invention relates to the use of the diastereomer-enriched odorant mixture for imparting, modifying or enhancing a floral odour note of a perfumed product or for the preparation of a perfumed product. Finally, the present invention also relates to odorant compositions and perfumed products comprising the diastereomer-enriched odorant composition.
Claims20
A distillative process for the preparation of a diastereomer-enriched odorant mixture comprising compounds of the general formula (A):
- wherein the odorant mixture comprises the following mutually diastereomeric pairs of enantiomers:
- wherein the ratio of the enantiomeric pair (I) and the enantiomeric pair (II) to one another is at least 10:1;
- wherein the ratio of the enantiomer pairs (I) and (III) to each other is at least 50:1;
- and
- wherein the process comprises the following distillation steps:
- (a) separating by distillation a crude product comprising compounds of the general formula (A) in a first distillation step;
- (b) subsequently fine distilling the crude product over one or more distillation steps to concentrate the enantiomeric pair (I) relative to the enantiomeric pairs (II) and (III), wherein the fine distillation comprises at least 15 separation steps.
A diastereomer-enriched odorant mixture comprising compounds of the general formula (A):
- wherein the compounds of formula (A) comprise the following mutually diastereomeric enantiomer pairs of formulae (I), (II) and (III):
- wherein the ratio of the enantiomeric pair (I) and the enantiomeric pair (II) to each other is at least 10:1;
- and
- wherein the ratio of the enantiomer pairs (I) and (III) to each other is at least 50:1.
Dependencies are inferred from the claim text.