Benzylamine derivative, preparation method therefor and use thereof

A benzylamine derivative of general Formula (I), or a pharmaceutically acceptable stereoisomer, salt solvate or prodrug thereof,

• wherein,
• R is selected from the group consisting of hydrogen and C1-C8 alkyl;
• R1 is selected from the group consisting of hydrogen, deuterium, halogen, C1-C4 alkyl, deuterated C1-C4 alkyl, halogenated C1-C4 alkyl and C1-C4 alkoxy;
• R2 is selected from the group consisting of
• wherein R6 is selected from the group consisting of halogen, C1-C4 alkyl, deuterated C1-C4 alkyl, halogenated C1-C4 alkyl and C1-C4 alkoxy, R7 is at the meta or ortho position of R6 and R7 is selected from the group consisting of hydrogen, —O—(CH2)n—R0, —CONH—R0 and —(CH2)n—R0, wherein n is an integer of 1-4, R0 is cyano, hydroxyl, carboxyl, amino or a heteroatom-containing linear or cyclic hydrophilic substituent;
• R3 is selected from R8—CH2—, wherein R5 is selected from the group consisting of hydrogen, cyano, C1-C4 alkyl, halogenated C1-C4 alkyl, C2-C4 alkenyl, —NR9R10, —CONR9R10, 3- to 6-membered cycloalkyl, 3- to 6-membered heterocycloalkyl, 6- to 10-membered aryl and 5- to 10-membered heteroaryl, optionally, the C1-C4 alkyl, halogenated C1-C4 alkyl, C2-C4 alkenyl, —NR9R10, —CONR9R10, 3- to 6-membered cycloalkyl, 3- to 6-membered heterocycloalkyl, 6- to 10-membered aryl, and 5- to 10-membered heteroaryl that are each independently substituted with one or more substituents selected from the group consisting of cyano, halogen, carboxyl, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylsulfonyl, 3- to 6-membered cycloalkyl, hydroxyl-substituted 3 to 6-membered cycloalkyl, 3- to 6-membered heterocycloalkyl, hydroxyl-substituted 3- to 6-membered heterocycloalkyl, —CONR9R10 and —NR9COR10, wherein R9 and R10 at each occurrence are each independently selected from the group consisting of hydrogen, deuterium and C1-C4 alkyl;
• R4 is selected from the group consisting of hydroxyl, carboxyl, fragment of amino acid and —NR10R11, wherein R10 and R11 are each independently selected from the group consisting of hydrogen, deuterium, C1-C6 alkyl and 3- to 6-membered cycloalkyl, optionally, the C1-C6 alkyl and 3- to 6-membered cycloalkyl are each independently substituted with one or more substituents selected from the group consisting of mercapto group, hydroxyl, carboxyl, hydroxyl-substituted C1-C6 alkyl, C1-C6 amido and 3- to 6-membered nitrogen-containing heterocycloalkyl;
• or, R10 and R11 together with the N atom connected therewith form a 5- to 6-membered heterocycloalkyl, optionally, the 5- to 6-membered heterocycloalkyl is substituted with one or more groups selected from the group consisting of amino, hydroxyl, carboxyl, mercapto group and hydroxyl-substituted C1-C6 alkyl;
• R5 is selected from the group consisting of hydrogen, deuterium, cyano, halogen, C1-C4 alkyl, C2-C4 alkenyl, deuterated C1-C4 alkyl, halogenated C1-C4 alkyl and C1-C4 alkoxy;
• Y and Z are each independently selected from the group consisting of carbon and nitrogen.