Broad spectrum antivirals against coronavirus
AssigneesKansas State University Research Foundation, Wichita State University, University of Iowa Research Foundation
InventorsKyeong-Ok Chang, Yunjeong Kim, William C. Groutas, Stanley Perlman
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Abstract
Compounds exhibiting antiviral activity and/or inhibition of viral replication against viruses, particularly those belonging to the picornavirus-like supercluster, including coronavirus having a formula: (I) where X comprises a cyclic moiety, R2 is a branched or unbranched alkyl, cycloalkyl, aryl, arylalkyl, alkenyl, alkynyl, amino acid side chain, bicyclic or tricyclic side chain, combinations, and substituted forms thereof, and Z is selected from the group consisting of C1-C6 hydroxyalkyl, aldehydes, alpha-ketoamides, and bisulfite salts, and in particular —CH2OH, —CHO, —CH(0H)S03−Na+, and -[0(C=0)Rw]S03−Na+.
Claims12
A compound comprising of formula I:
- or a pharmaceutically acceptable salt thereof, where:
- X is selected from the following structures shown in brackets with the oxygen linkage from formula (I) depicted for clarity:
- and
- R2 is a branched or unbranched C1-C6 alkyl, C3-C10 cycloalkyl, C6-10 aryl, C1-C6 alkylene-C6-10 aryl, C2-C6 alkenyl, C2-C6 alkynyl, bicyclic or tricyclic moiety, or a combination thereof, wherein C1-C6 alkyl is optionally substituted with one or more halogen, —OH, —SH, —SCH3, —NH2, —COOH, —C(O)NH2, —NH(C═NH)NH2, C3-C10 cycloalkyl, C6-10 aryl optionally substituted with —OH, or 5-9 membered heteroaryl having 1-3 ring heteroatoms selected from N, O, and S;
- and
- Z is selected from the group consisting of C1-C6 hydroxyalkyl, aldehydes, alpha-ketoamides, and bisulfite salts, —CH2OH, —CHO, —CH(OH)SO3−Na+, —[O(C═O)CH3]SO3−Na+, and —[O(C═O)CH2CH3]SO3−Na+.
Dependencies are inferred from the claim text.