Compound, preparation method thereof, and use thereof

A compound represented by formula 1, a stereoisomer thereof or a pharmaceutically acceptable salt thereof:

• wherein Ar is 6-10 membered aryl or 5-6 membered heteroaryl containing one to two heteroatoms selected from the group consisting of N, S and O;
• R1 and R2 are independently hydrogen or halogen;
• R3 is substituted straight or branched C1-8 alkyl, NRa1Ra2, ORa3,
• wherein Ra1 is hydrogen, Ra2 and Ra3 are independently substituted straight or branched C1-8 alkyl, nonsubstituted or substituted phenyl or nonsubstituted or substituted 5-6 membered heteroaryl containing one to three heteroatoms selected from the group consisting of N, S and O,
• wherein the substituted alkyl is substituted with one substituent selected from the group consisting of nonsubstituted or substituted 4-8 membered heterocycloalkyl containing one to two heteroatoms selected from the group consisting of N, S and O, and nonsubstituted or substituted 4-6 membered heteroaryl containing one to three heteroatoms selected from the group consisting of N, S and O, and the substituted alkyl is optionally further substituted with hydroxy or to form 3-6 membered cycloalkyl with substituted carbon,
• the substituted phenyl and the substituted 5-6 membered heteroaryl are independently substituted with one to three substituents selected from the group consisting of 4-8 membered nonsubstituted or substituted heterocycloalkyl containing one to two heteroatoms selected from the group consisting of N, S and O, and halogen, and
• the substituted 4-8 membered heterocycloalkyl and the substituted 4-6 membered heteroaryl are substituted with one to three substituents selected from the group consisting of straight or branched C1-5 alkyl nonsubstituted or substituted with one or more straight or branched C1-5 alkylcarbonyl, NRb1Rb2, halogen, hydroxy and oxo,
• Rb1 and Rb2 are independently hydrogen, or straight or branched C1-6 alkyl;
• L1 is
• wherein Rc is hydrogen;
• L2 is straight or branched C1-8 alkylene nonsubstituted or substituted with hydroxy;
• Z is C3-8 cycloalkyl fused with nonsubstituted or substituted 9 membered heteroaryl containing one or two heteroatoms of N, substituted 9 membered heteroaryl containing one or two heteroatoms of N, or substituted 9 membered heteroaryl C1-5 alkyl containing one or two heteroatoms of N,
• wherein the substituted 9 membered heteroaryl and the substituted 9 membered heteroaryl C1-5 alkyl are independently substituted with halogen and optionally further substituted with straight or branched C1-5 alkyl.