Lipids for lipid nanoparticle delivery of active agents

A compound having the following structure (I):

• or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein:
• G1 is —N(R3)R4 or —OR5;
• R1 is branched, saturated or unsaturated, optionally substituted C12-C36 alkyl;
• R2 is branched or unbranched, saturated or unsaturated, optionally substituted C12-C36 alkyl when L is —C(═O)—;
• or R2 is branched or unbranched, saturated or unsaturated, optionally substituted C4-C36 alkyl when L is C6-C12 alkylene, C6-C12 alkenylene, or C2-C6 alkynylene;
• R3 and R4 are each independently branched or unbranched, saturated or unsaturated, optionally substituted C1-C6 alkyl, or R3 and R4, together with the nitrogen to which they are attached, join to form a heterocyclyl;
• R5 is H or optionally substituted C1-C6 alkyl;
• L is —C(═O)—, C6-C12 alkylene, C6-C12 alkenylene, or C2-C6 alkynylene;
• and
• n is an integer from 1 to 12.