Separation matrix and method of separation
AssigneeCytiva BioProcess R&D AB
InventorsJean-Luc Maloisel, Jimmy Hedin Dahlström, Marc Hummersone, Ola Lind, Sara Häggblad Sahlberg, Jon Lundqvist, Tania Ahmad
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Abstract
The invention discloses a separation matrix comprising a plurality of multimodal ligands covalently coupled to a support, wherein said support is a membrane comprising nonwoven polymer fibers and wherein said ligands are capable of interacting with a target biomacromolecule. Further, the invention discloses separation methods using the separation matrix.
Claims34
A separation matrix comprising a plurality of multimodal ligands covalently coupled to a support, wherein said support is a membrane comprising nonwoven polymer fibers and wherein said ligands comprise multimodal cation exchange ligands and are capable of interacting with a target biomacromolecule, wherein said multimodal cation exchange ligands comprise copolymer chains comprising units derived from
- a) a first monomer of structure CH2═CH-L4-X1, where L4 is a covalent bond or an alkyl ether or hydroxyl substituted alkyl ether chain comprising 2-6 carbon atoms, and X1 is a sulfonate or phosphonate group and
- b) a second non-charged vinyl amide monomer.
The separation matrix of, wherein said multimodal cation exchange ligands comprise ligands of structure
- coupled to the support via the sulfur.
Dependencies are inferred from the claim text.