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US 12,582,849 B2Granted
Determining ultrasound-based blood-brain barrier opening or increased permeability using physiologic signals
AssigneeCordance Medical Inc.
InventorBhaskar Singenellore Ramamurthy
Life of this patent
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Abstract
Examples are directed to devices, methods, and systems for determining opening or increased permeability of a blood-brain barrier (BBB) of a patient. An example device comprises memory circuitry that stores a set of non-transitory instructions, and processor circuitry coupled to the memory circuitry and configured to execute the instructions to determine opening or increased permeability of a BBB of a patient during an ultrasound-based BBB opening procedure using physiologic signals obtained from the patient.
Claims20
A device comprising:
- memory circuitry that stores a set of non-transitory instructions;
- and
- processor circuitry coupled to the memory circuitry and in communication with a sensor configured to capture physiologic signals from a patient and communicate the physiological signals to the processor circuitry and a focused ultrasound system (FUS), the processor circuitry being configured to execute the instructions to:
- determine opening or increased permeability of a blood-brain barrier (BBB) of the patient during an ultrasound-based BBB opening procedure performed by the FUS by monitoring energy in predefined bands of frequency within the physiologic signals, as received from the sensor, for a change in the physiologic signals;
- and
- in response, control the ultrasound-based BBB opening procedure as a result of the change in the physiologic signals.
3 more elements
A method comprising:
- obtaining physiologic signals from a patient by a sensor configured to capture the physiologic signals and communicate the physiological signals to processor circuitry;
- and
- determining, via the processor circuitry, opening or increased permeability of a blood-brain barrier (BBB) of the patient during an ultrasound-based BBB opening procedure as performed by a focused ultrasound system (FUS) by monitoring energy in predefined bands of frequency within the physiologic signals for a change in the physiologic signals;
- and
- in response, controlling, via the processor circuitry in communication with the FUS, the ultrasound-based BBB opening procedure as performed by the FUS as a result of the change in the physiologic signals.
2 more elements
A system comprising:
- a sensor configured to capture physiologic signals from a patient;
- a focused ultrasound system (FUS) configured to open or increase permeability of a blood-brain barrier (BBB) of the patient using a focused ultrasound;
- and
- processor circuitry in communication with the sensor and the FUS and being configured to:
- obtain the physiologic signals from the sensor;
- and
- determine opening or increased permeability of the BBB of the patient during an ultrasound-based BBB opening procedure using the physiologic signals received from the sensor during the ultrasound-based BBB opening procedure;
- and
- control the ultrasound-based BBB opening procedure as performed by the FUS as a result of a change in the physiologic signals obtained during the ultrasound-based BBB opening procedure.
6 more elements
Dependencies are inferred from the claim text.