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US 12,582,829 B2Granted
Plasma treatment devices and methods of use thereof
AssigneeTheraDep Technologies, Inc.
InventorsMichael Fourkas, Denis O'Sullivan, Liam O'Neill, Joseph M. Tartaglia
Life of this patent
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Abstract
Medical devices for generating an aerosol and plasma, e.g., for therapeutic treatment are described. The medical device may include a nebulizer, the nebulizer including an outer compartment, an inner compartment, and a needle radially inward of the inner and outer compartments. The medical device may include at least one electrode and a chamber, wherein a distal-facing surface of the chamber defines at least one plasma outlet and a nozzle in communication with the nebulizer, an end of the electrode being proximate the plasma outlet.
Claims29
A medical device comprising:
- a housing that includes a nebulizer, the nebulizer comprising:
- an outer compartment in communication with a gas inlet,
- an inner compartment in communication with a fluid channel and a fluid inlet, and
- a needle;
- wherein the needle is radially inward of the inner compartment, the inner compartment is radially inward of the outer compartment, and a distal end of the outer compartment is in communication with a distal end of the inner compartment;
- at least one electrode;
- and
- a chamber defined by a distal end portion of the housing;
- wherein a distal-facing surface of the chamber defines at least one plasma outlet and a nozzle in communication with the nebulizer;
- and
- wherein an end of the at least one electrode is proximate the plasma outlet, and wherein a proximal portion of the chamber is configured to receive an electrode tip of a plasma device and to electrically connect the electrode tip of the plasma device to the at least one electrode.
8 more elements
A medical device comprising:
- a housing that includes a nebulizer, the nebulizer comprising:
- an outer compartment,
- an inner compartment, and
- a needle;
- wherein the needle is radially inward of the inner compartment, the inner compartment is radially inward of the outer compartment, and a distal end of the outer compartment is in communication with a distal end of the inner compartment;
- a fluid reservoir coupled to a fluid inlet, the fluid reservoir containing a liquid that comprises at least one therapeutic agent;
- at least one electrode;
- and
- a chamber defined by a distal end portion of the housing;
- wherein a distal-facing surface of the chamber defines at least one plasma outlet and a nozzle in communication with the nebulizer;
- and
- wherein an end of the at least one electrode is proximate the plasma outlet;
- and
- wherein a proximal portion of the chamber is configured to receive an electrode tip of a plasma device and to electrically connect the electrode tip of the plasma device to the at least one electrode.
11 more elements
A medical device comprising:
- a housing that includes a nebulizer, the nebulizer comprising:
- an outer compartment in communication with a gas inlet,
- an inner compartment in communication with a fluid inlet, and
- a needle;
- wherein the needle is radially inward of each of the inner compartment and the outer compartment, and a distal end of the outer compartment is in communication with a distal end of the inner compartment;
- at least one electrode;
- a fluid reservoir coupled to the fluid inlet;
- and
- a chamber defined by a distal end portion of the housing;
- wherein a distal-facing surface of the chamber defines at least one plasma outlet and a nozzle in communication with the nebulizer;
- and
- wherein an end of the at least one electrode is proximate the plasma outlet;
- and
- wherein a proximal portion of the chamber is configured to receive an electrode tip of a plasma device and to electrically connect the electrode tip of the plasma device to the at least one electrode.
11 more elements
A method of treating tissue of a subject, the method comprising exposing the tissue to plasma and an aerosol comprising at least one therapeutic agent using a medical device, the medical device comprising:
- a housing that includes a nebulizer, the nebulizer comprising:
- an outer compartment in communication with a gas inlet,
- an inner compartment in communication with a fluid channel and a fluid inlet, wherein the fluid channel receives a fluid that comprises the at least one therapeutic agent, and
- a needle;
- wherein the needle is radially inward of the inner compartment, the inner compartment is radially inward of the outer compartment, and a distal end of the outer compartment is in communication with a distal end of the inner compartment;
- at least one electrode;
- and
- a chamber defined by a distal end portion of the housing;
- wherein a distal-facing surface of the chamber defines at least one plasma outlet and a nozzle in communication with the nebulizer;
- wherein an end of the at least one electrode is proximate the plasma outlet;
- wherein a proximal portion of the chamber receives an electrode tip of a plasma device and electrically connects the electrode tip of the plasma device to the at least one electrode;
- and
- wherein the plasma device generates the plasma and the nebulizer generates the aerosol exposed to the tissue.
10 more elements
Dependencies are inferred from the claim text.