Neurostimulation therapy for treating uterine bleeding

A method for treating uterine bleeding, the method comprising:

• applying, at least once within each forty-eight-hour period of a plurality of consecutive forty-eight-hour periods in which a subject exhibits or is expected to exhibit menstrual bleeding, neurostimulation therapy in one or more sessions, each session of the one or more sessions having a duration of at least five minutes, the neurostimulation therapy being configured to treat uterine bleeding in the subject, wherein
• applying the neurostimulation therapy comprises applying electrical neurostimulation or mechanical neurostimulation to directly and/or indirectly activate one or more neural targets, the one or more neural targets including at least one of a trigeminal cervical complex (TCC) or vagal efferent fibers (VEF), and
• the neurostimulation therapy is configured to enhance platelet function of the subject, thereby reducing a total volume of blood loss over a course of the menstrual bleeding wherein
• enhancing platelet function comprises increasing a baseline ionized calcium concentration in platelets of the subject.