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US 12,582,809 B2Granted
Treatment of a disease of the gastrointestinal tract with a PDE4 inhibitor
AssigneeBT Bidco, Inc.
InventorsMitchell Lawrence Jones, Sharat Singh, Christopher Loren Wahl, Harry Stylli, Kevin David Howe, Aruna Perera
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Abstract
This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a PDE4 inhibitor.
Claims20
A method of treating ulcerative colitis in a subject, the method comprising orally administering to the subject an ingestible device comprising:
- an ingestible housing comprising a reservoir, the reservoir containing a pharmaceutical formulation comprising a therapeutically effective amount of a small molecule phosphodiesterase 4 (PDE4) inhibitor and not comprising any additional therapeutic agent;
- a release mechanism having a closed state wherein the pharmaceutical formulation is retained in the reservoir and an open state which allows for the release of the pharmaceutical formulation from the reservoir to the exterior of the ingestible device;
- an actuator which controls the transition of the release mechanism from the closed state to the open state;
- a light source configured to produce light that interacts with the subject's gastrointestinal (GI) tract to provide light reflectance;
- a detector configured to detect the light reflectance to detect the GI tract;
- and
- a processor coupled to the detector and to the actuator, wherein the processor triggers the actuator to cause the release mechanism to transition from the closed state to the open state when the ingestible device is located in the cecum based on the detected light reflectance, wherein the cecum has been predetermined to be proximal to one or more disease sites,
- thereby releasing the pharmaceutical formulation comprising the PDE4 inhibitor from the ingestible device when the ingestible device is located in the cecum of the subject, and
- wherein the ingestible device comprises a pressure generating cell configured to generate an internal pressure that forces a release mechanism from a closed state, which retains the PDE4 inhibitor in the reservoir, to an open state, thereby allowing for the release of the PDE4 inhibitor from the reservoir to the exterior of the device.
6 more elements
A method of treating ulcerative colitis in a subject, the method comprising orally:
- administering to the subject an ingestible device comprising:
- an ingestible housing comprising a reservoir, the reservoir containing a pharmaceutical formulation comprising a therapeutically effective amount of a small molecule phosphodiesterase 4 (PDE4) inhibitor;
- a release mechanism having a closed state wherein the pharmaceutical formulation is retained in the reservoir and an open state which allows for the release of the pharmaceutical formulation from the reservoir to the exterior of the ingestible device;
- an actuator which controls the transition of the release mechanism from the closed state to the open state;
- a light source configured to produce light that interacts with the subject's gastrointestinal (GI) tract to provide light reflectance;
- a detector configured to detect the light reflectance to detect the GI tract;
- and
- a processor coupled to the detector and to the actuator, wherein the processor triggers the actuator to cause the release mechanism to transition from the closed state to the open state when the ingestible device is located in the cecum based on the detected light reflectance, wherein the cecum has been predetermined to be proximal to one or more disease sites, thereby releasing the pharmaceutical formulation comprising the PDE4 inhibitor from the ingestible device when the ingestible device is located in the cecum of the subject, and
- wherein the ingestible device comprises a gas generating cell located within the housing, wherein the gas generating cell is capable of generating a gas;
- and the ingestible device is configured so that, when the gas generating cell generates the gas, the gas creates an internal pressure that forces a release mechanism from a closed state, which retains the PDE4 inhibitor in the reservoir, to an open state, thereby allowing for the release of the PDE4 inhibitor from the reservoir to the exterior of the device.
7 more elements
Dependencies are inferred from the claim text.