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US 12,582,783 B2Granted
Dry powder inhalers and interfaces for improved aerosol delivery to children
AssigneeVirginia Commonwealth University
InventorsWorth Longest, Dale Farkas, Karl Bass, Michael Hindle
Life of this patent
Estimating the term…
Abstract
Exemplary embodiments include dry powder inhalers (DPIs) and patient interfaces which improve delivery of aerosols to patients, especially children.
Claims25
A device for patient interfacing and administration of an aerosol to be delivered to the lungs, comprising
- a lumen with one or more exit orifices leading to a recipient;
- a 3D rod array arranged in the lumen, wherein the 3D rod array comprises a plurality of rows, wherein each row has a plurality of unidirectional rods which extend between opposite walls of the lumen, wherein the plurality of rows are spaced apart from one another along a primary flow axis of the lumen such that the rods do not contact one another;
- a capillary configured to pass a flow of drug aerosol;
- and
- at least one drug aerosol inlet orifice for delivering a drug aerosol air jet from the capillary to the lumen,
- wherein proximity of the drug aerosol inlet orifice to a first row of the 3D rod array is such that the drug aerosol air jet from the capillary is forced to flow through the 3D rod array, and
- wherein at least one cross-sectional dimension of the lumen is increased relative to the diameter of the at least one drug aerosol inlet orifice, wherein the increase in the at least one cross-sectional dimension begins at or before the at least one drug aerosol inlet orifice, wherein the at least one cross-sectional dimension of the lumen is oriented perpendicular to a long axis of the rods of the 3D rod array.
4 more elements
An air jet dry powder inhaler (DPI) system, comprising
- an air jet DPI, comprising
- a fixed position elongate aerosolization chamber with a longitudinal axis,
- one or more inlets for forming at least one cross flow air jet with an air jet axis, wherein the air jet axis is at a non-zero angle with the longitudinal axis of the aerosolization chamber, wherein the one or more inlets are flow passages or first orifices, and
- one or more outlets leading off the aerosolization chamber, wherein the one or more outlets are flow passages or second orifices;
- and
- a patient interface, comprising
- a lumen with one or more exit orifices,
- a 3D rod array arranged in the lumen, wherein the 3D rod array comprises a plurality of rows, wherein each row has a plurality of unidirectional rods which extend between opposite walls of the lumen, wherein the plurality of rows are spaced apart from one another along a primary flow axis of the lumen such that the rods do not contact one another,
- a capillary configured to pass a flow of drug aerosol from the aerosolization chamber toward the lumen, and
- at least one drug aerosol inlet orifice for delivering a drug aerosol air jet from the capillary to the lumen,
- wherein proximity of the drug aerosol inlet orifice to a first row of the 3D rod array is such that the drug aerosol air jet from the capillary is forced to flow through the 3D rod array, and
- wherein at least one cross-sectional dimension of the lumen is increased relative to the diameter of the at least one drug aerosol inlet orifice, wherein the increase in the at least one cross-sectional dimension begins at or before the at least one drug aerosol inlet orifice, wherein the at least one cross-sectional dimension of the lumen is oriented perpendicular to a long axis of the rods of the 3D rod array.
9 more elements
Dependencies are inferred from the claim text.