US 12,582,747 B2 · Implantable biomaterial, and method of manufacturing thereof

Abstract

A method of forming an implantable biomaterial comprising the steps of providing a polyether-diisocyanate prepolymer, reacting the prepolymer with one or more chain extender molecules typically including benzene 1,4-diol to form a mouldable polymer selected from a polyurethane or polyurethane-urea polymer or a polyurethane-urea block copolymer; placing the mouldable polymer into an implantable biomaterial shaped mould, and shaping and curing the mouldable polymer in the implantable biomaterial shaped mould to form the implantable biomaterial. An implantable biomaterial such as a heart valve leaflet is also disclosed.

Claims15

Dependent claims

An implant comprising a shaped and cured implantable flexible biomaterial formed by:

providing a polyether-diisocyanate prepolymer formed by reacting a polyether with a toluene diisocyanate;
reacting the prepolymer with one or more chain extender molecules, said one or more chain extender molecules comprising benzene-1,4-diol and a chain extender molecule having amine functionality;
optionally, in which the chain extender molecule having amine functionality is p-phenylene diamine;
wherein reacting the prepolymer with the one or more chain extender molecules form a mouldable polymer selected from a polyurethane polymer, a polyurethane-urea polymer, or a polyurethane-urea block copolymer;
and
shaping and curing the mouldable polymer to form the implantable biomaterial, wherein the mouldable polymer exhibits the hydrogen bonded microphase separated morphology.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

17/266,227Filed 7 Aug 2019

Priority

EP 181877157 Aug 2018

Published

US 2021/0299324 A130 Sep 2021

Granted

24 Mar 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification12 codes

A61L 27/18
Macromolecular materials: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A61L 27/507
Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface…:…
A61L 29/06
Macromolecular materials: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A61L 31/06
Macromolecular materials: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds

Implantable biomaterial, and method of manufacturing thereof

Life of this patent

Implantable biomaterial, and method of manufacturing thereof

Life of this patent

Abstract

Claims15