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US 12,582,729 B2Granted
Kit technology for the production and long-term storage of Zr-89-PET radiopharmaceuticals
AssigneeWake Forest University Health Sciences
InventorsThaddeus J. Wadas, Nikunj B. Bhatt, Darpan N. Pandya
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Abstract
The present invention is directed to radiopharmaceuticals with improved stability, a kit, and a method of production thereof.
Claims14
A radiopharmaceutical system comprising a complex and an effective amount of a radioprotectant for stabilizing the complex, wherein
- (a) the complex comprises a 89Zr-labeled conjugate comprising 89Zr coordinated to a chelator, and wherein the chelator is conjugated to an antibody selected from cetuximab or trastuzumab, wherein the chelator is selected from the group consisting of desferrioxamine B (DFO) and derivatives thereof;
- and
- (b) the radioprotectant comprises an effective amount of N-acetyl-L-cysteine.
Dependencies are inferred from the claim text.