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US 12,582,727 B2Granted
Chemiluminescent and fluorescent nanoparticle for optical imaging of cancer
AssigneeThe Regents of the University of Colorado, a body corporate
InventorJung-Jae Lee
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Abstract
The present invention provides compositions and methods for detecting tumor tissues in a subject. Embodiments of the present invention provide biocompatible chitosan nanoparticles suitable for dual modality optical imaging. Embodiments of the present invention provide methods for fabricating chitosan nanoparticles. Embodiments of the present invention provide methods for detecting tumor tissues in a subject using compositions provided by the present invention.
Claims10
A chitosan-based nanoparticle comprising
- a glycol chitosan nanoparticle conjugated to (i) a photosensitizer, (ii) a targeting ligand, and (iii) a singlet oxygen releasing agent,
- wherein the singlet oxygen releasing agent exists in an oxygen-free form or in an oxygen-loaded form,
- wherein the targeting ligand comprises folate, PSMAi, or bis-Zn-DPA,
- wherein the photosensitizer conjugated to the glycol chitosan has the chemical structure:
- wherein the nanoparticle is configured to transfer energy from the singlet oxygen releasing agent to the photosensitizer,
- wherein the nanoparticle comprises the following chemical structure when the singlet oxygen releasing agent is in the oxygen-free form:
- wherein:
- R3 is H;
- and
- R1, R2, and R4 are each independently H or CH3.
7 more elements
Dependencies are inferred from the claim text.