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US 12,582,719 B2Granted
Chimeric compounds and methods of managing neurological disorders or conditions
AssigneeEmory University
InventorsHyunsuk Shim, Huw Davies, Hyun Park, Yoon Hyeun Oum
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Abstract
This disclosure relates to chimeric compounds and methods for managing neurological conditions. In certain embodiments, the compound comprises a chemical structure of a monoamine reuptake inhibitor conjugated to a chemical structure of a histone deacetylase inhibitor. In certain embodiments, this disclosure relates to methods of treating or preventing a neurological disorder, mental disorder or depression comprising administering an effective amount of a compound disclosed herein to a subject in need thereof.
Claims12
A compound having formula IA
- or salt thereof wherein,
- X is O or NR4,
- Y is NR4;
- R2 is hydrogen or C1-4alkyl;
- R3 is hydrogen or C1-4alkyl;
- R4 is hydrogen or C1-4alkyl;
- R5, R6, R8, and R9 are hydrogen;
- R12 is hydrogen, alkyl, hydroxy or aryl, wherein R12 is optionally substituted with one or more, the same or different, R20;
- R13, R14, and R15 are, individually and independently, hydrogen, alkyl, or halogen;
- and
- R20 is alkyl, halogen, hydroxy, amino, or mercapto.
8 more elements
Dependencies are inferred from the claim text.