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US 12,582,711 B2Granted
RNA-based adjuvant to enhance the immune response to vaccines and therapeutics
AssigneeImmunesure LLC
InventorsPatrick Iversen, Nickolas Kipshidze, Nodar Kipshidze
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Abstract
Described herein are antisense inhibitor adjuvant compositions comprising modified nucleotide sequences complementary to a Homo sapiens interleukin 10 (IL-10) or interleukin 10 receptor alpha (IL-10RA) genes and methods for use thereof.
Claims22
An adjuvant composition comprising:
- one or more antisense nucleotide sequences complementary to a human interleukin 10 mRNA having a single mismatch and selected from SEQ ID NO:
- 2-6;
- or
- one or more antisense nucleotide sequences complementary to a human interleukin 10 receptor alpha mRNA comprising nucleotides having a single mismatch and selected from SEQ ID NO:
- 7-10.
2 more elements
Dependencies are inferred from the claim text.