Single-chain coronavirus viral membrane protein complexes
AssigneeUniversity of Houston System
InventorsKe-He Ruan, Xinli Liu, Renzhong Lu
Life of this patent
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Abstract
Recombinant protein coronavirus antigens and vaccine compositions using the same, include a recombinant protein that is a single-chain (SC) viral membrane protein complex derived from the spike (S), envelop (E) and membrane (M) protein of a coronaviruses such as SARS-CoV-2, the causal agent for COVID-19. Methods for immunization of a subject using the vaccine compositions treats or prevents clinical signs caused by coronaviruses infection.
Claims21
A coronavirus single-chain (SC) membrane protein comprising a viral spike (S) protein, a viral envelope (E) protein, and a viral membrane (M) protein and, optionally, one or more linker sequences wherein:
- (i) the viral(S) protein comprises the amino acid sequence of SEQ ID NO:
- 1, or an amino acid sequence having at least 95% sequence identity to SEQ ID NO:
- 1;
- (ii) the viral (E) protein comprises the amino acid sequence of SEQ ID NO:
- 2, or an amino acid sequence having at least 95% sequence identity to SEQ ID NO:
- 2;
- and
- (iii) the viral (M) protein comprises the amino acid sequence of SEQ ID NO:
- 3, or a sequence having at least 95% sequence identity to SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.