Back to results
US 12,582,709 B2Granted
Persistent memory T-cell responses to cancer and infectious-disease antigens by manipulation of amino acid-catabolism pathways
AssigneeThe Regents of the University of California
InventorDennis Hartigan-O'Connor
Life of this patent
Estimating the term…
Abstract
Provided herein are recombinant polynucleotides including a first nucleic acid sequence encoding an antigen, and a second nucleic acid sequence encoding an enzyme of an amino acid catabolic pathway. The provided recombinant polynucleotides are particularly useful for inducing long-lived immune responses having improved memory characteristics. Also provided are pharmaceutical compositions, viral particles, and host cells including the disclosed recombinant polynucleotides, and methods for using the disclosed materials.
Claims19
A recombinant polynucleotide comprising:
- a first nucleic acid molecule encoding an antigen;
- and
- a second nucleic acid molecule encoding an enzyme of an amino acid catabolic pathway, wherein the amino acid catabolic pathway comprises an L-tryptophan catabolic pathway or an L-arginine catabolic pathway.
Dependencies are inferred from the claim text.