Recombinant influenza viruses comprising truncated NS1 fusion proteins
AssigneeI.D.Bio.
InventorsYoung-Jae Si, Hyuk-Il Kwon, Yeo-Jeong Choi
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Abstract
The present disclosure relates to a novel recombinant influenza virus, in which an interferon-beta gene, which is a foreign gene associated with an antiviral action, is introduced to an NS1 gene which is an influenza virus gene that is expressed first in the host to suppress the host immune system when infected with the influenza virus, and, in contrast to existing research, the interferon-beta is separated from the NS1 protein to carry out an intrinsic function of interferon-beta of inducing an antiviral action.
Claims6
A recombinant influenza virus comprising a nucleic acid encoding a truncated NS1 protein of SEQ ID NO:
- 12.
A genetic vector comprising a nucleic acid encoding a truncated NS1 protein of SEQ ID NO:
- 12.
Dependencies are inferred from the claim text.