Methods for improving leptin sensitivity for the treatment of obesity and diabetes
AssigneeUniversity of Massachusetts
InventorsYong-Xu Wang, Lei Huang, Yong Du
Life of this patent
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Abstract
Methods for altering leptin resistance and the hormonal control of energy balance, and methods for treating obesity and diabetes, as well as promoting weight gain, using batotin and batotin inhibitors.
Claims16
A method of treating, or reducing risk of, a disorder associated with obesity, or improving glycemic control, in a mammalian subject, the method comprising administering a therapeutically effective amount of an inhibitory nucleic acid that is 10 to 50 nucleotides in length and binds to and inhibits expression of a batotin nucleic acid of SEQ ID NO:8 to a subject in need thereof, wherein the inhibitory nucleic acid is an antisense oligonucleotide, a short interfering RNA (siRNA), or a short, hairpin RNA (shRNA), and wherein the inhibitory nucleic acid comprises a sequence of 10 to 50 nucleotides that is 100% complementary to 10 to 50 nucleotides consecutive nucleotides of SEQ ID NO:8.
A method of decreasing body weight or fat in a mammalian subject in need thereof, the method comprising administering a therapeutically effective amount of an inhibitory nucleic acid that is 10 to 50 nucleotides in length and binds to and inhibits expression of a batotin nucleic acid of SEQ ID NO:8 to a subject in need thereof, wherein the inhibitory nucleic acid is an antisense oligonucleotide, a short interfering RNA (siRNA), or a short, hairpin RNA (shRNA), and wherein the inhibitory nucleic acid comprises a sequence of 10 to 50 nucleotides that is 100% complementary to 10 to 50 nucleotides consecutive nucleotides of SEQ ID NO:8.
Dependencies are inferred from the claim text.