Compositions and methods for enhanced lymphocyte-mediated immunotherapy
AssigneesProvincial Health Services Authority, Universite Laval
InventorsJulian J. Lum, Lindsay Devorkin, Yannick Doyon, Gillian Carleton
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Abstract
Lymphocytes having a suppressed autophagy gene useful in immunotherapy are disclosed. The lymphocytes can express an antigen targeting receptor such as a chimeric antigen receptor (CAR) or endogenous or engineered T-cell receptor to target cells expressing a tumor-specific antigen. Methods of making and using such lymphocytes are disclosed. Some such lymphocytes are useful in conducting CAR-T or TCR-T therapy.
Claims19
A lymphocyte comprising an antigen targeting receptor and a suppressed autophagy gene, wherein the antigen targeting receptor comprises a chimeric antigen receptor (CAR) or an engineered T-cell receptor.
Dependencies are inferred from the claim text.