Compositions and methods for treating glioma

An isolated peptide for inhibiting GM-CSF activity, said peptide being of 10-20 amino acids and comprising an amino acid sequence selected from the group consisting of:

• an amino acid sequence set forth in SEQ ID NO:
• 1 or variants thereof, SEQ ID NO:
• 23, and SEQ ID NO:
• 24, wherein each of the variants of SEQ ID NO:
• 1 is selected from SEQ ID NO:
• 1 with substitution of amino acids in any one or more of positions 2, 3, 5, 6, 9 and 11-13 with alanine or lysine and with or without addition of lysine at the N-terminus of SEQ ID NO:
• 1.