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US 12,582,683 B2Granted
Prostate neoantigens and their uses
AssigneeJanssen Biotech, Inc.
InventorsKurtis E. Bachman, Vipul Bhargava, Darryl L. Davis, Vinod Krishna, Guido Leoni, David Pocalyko, Pegah Safabakhsh, Manuel Sepulveda, Derick Siegel, Marco Gottardis
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Abstract
The disclosure relates to prostate neoantigens, polynucleotides encoding them, vectors, host cells, recombinant virus particles, vaccines comprising the neoantigens, proteinaceous molecules binding the prostate neoantigens, and methods of making and using them.
Claims23
A method of treating prostate cancer in a subject, the method comprising administering to the subject a therapeutically effective amount of a vaccine comprising:
- a) a heterologous polynucleotide encoding a heterologous polypeptide comprising SEQ ID NOs:
- 275, 381, 333, 337, 269, 253, 309, 325, 271, 305, 251, 245, 261, 265, 317, 255, 297, 285, 437, 439, 442, 444, 379, 343, 211, 349, 213, 215, 221, 219, 225, 345, 353, 235, 223, 167, 171, 19, 23, and 177;
- or
- b) a heterologous polynucleotide comprising SEQ ID NOs:
- 276, 382, 334, 338, 270, 254, 310, 326, 272, 306, 252, 246, 262, 266, 318, 256, 298, 286, 448, 450, 453, 455, 380, 344, 212, 350, 214, 216, 222, 220, 226, 346, 354, 236, 224, 168, 172, 20, 24, and 178.
2 more elements
Dependencies are inferred from the claim text.