Compositions and methods for the treatment of allergy
AssigneeVedanta Biosciences, Inc.
InventorsRose L. Szabady, Bernat Olle, Bruce Roberts
Life of this patent
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Abstract
Provided herein are compositions and methods for the treatment of allergy, such as food allergy. Also provided herein are compositions and methods for modulating an immune response associated with allergy and/or inducing immune tolerance or desensitization to an allergy, such as a food allergy.
Claims19
A method of treating a food allergy, the method comprising orally administering to a subject in need thereof a therapeutically effective amount of a composition comprising:
- (i) a purified bacterial strain belonging to the species Clostridium bolteae;
- (ii) a purified bacterial strain belonging to the species Anaerotruncus colihominis;
- (iii) a purified bacterial strain belonging to the species Sellimonas intestinalis or Drancourtella massiliensis;
- (iv) a purified bacterial strain belonging to the species Clostridium symbiosum;
- (v) a purified bacterial strain belonging to the species Blautia producta;
- (vi) a purified bacterial strain belonging to the species Clostridium innocuum;
- and
- (vii) a purified bacterial strain belonging to the species Flavonifractor plautii.
A method of treating a food allergy, the method comprising orally administering to a subject in need thereof a therapeutically effective amount of a composition comprising:
- (i) a purified bacterial strain comprising a 16S rDNA sequence with at least 97% sequence identity to the nucleotide sequence of SEQ ID NO:
- 1;
- (ii) a purified bacterial strain comprising a 16S rDNA sequence with at least 97% sequence identity to the nucleotide sequence of SEQ ID NO:
- 2;
- (iii) a purified bacterial strain comprising a 16S rDNA sequence with at least 97% sequence identity to the nucleotide sequence of SEQ ID NO:
- 3;
- (iv) a purified bacterial strain comprising a 16S rDNA sequence with at least 97% sequence identity to the nucleotide sequence of SEQ ID NO:
- 4;
- (v) a purified bacterial strain comprising a 16S rDNA sequence with at least 97% sequence identity to the nucleotide sequence of SEQ ID NO:
- 5;
- (vi) a purified bacterial strain comprising a 16S rDNA sequence with at least 97% sequence identity to the nucleotide sequence of SEQ ID NO:
- 7;
- and
- (vii) a purified bacterial strain comprising a 16S rDNA sequence with at least 97% sequence identity to the nucleotide sequence of SEQ ID NO:
- 8.
Dependencies are inferred from the claim text.