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US 12,582,673 B2Granted
Extended use zirconium silicate compositions and methods of use thereof
AssigneeZs Pharma, Inc.
InventorsDonald Jeffrey Keyser, Alvaro F. Guillem
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Abstract
The present invention relates to zirconium silicate compositions having a lead content that is below 0.6 ppm and methods of manufacturing zirconium silicate at reactor volumes exceeding 200-L with a lead content below 1.1 ppm. The lead content of the zirconium silicate of this invention are within the levels that are considered acceptable for extended use given the dose requirements for zirconium silicate.
Claims12
A method of making zirconium silicate comprising:
- adding sodium hydroxide and water to a reactor to form a first mixture;
- adding colloidal silica to the first mixture in the reactor and agitating at a first agitation rate to obtain a second mixture;
- and,
- reducing the agitation rate to a second agitation rate that is lower than the first agitation rate and adding zirconium acetate to the second mixture, thereby reacting the colloidal silica with zirconium acetate to form zirconium silicate, wherein the zirconium silicate has a lead content of less than 0.6 ppm.
1 more element
Dependencies are inferred from the claim text.