Compositions and methods to treat metastatic gastrointestinal cancer
AssigneeThe Rockefeller University
InventorsSohail Tavazoie, Norihiro Yamaguchi, Kivanc Birsoy
Life of this patent
Estimating the term…
Abstract
The present invention relates to agents and methods for treating gastrointestinal cancer (e.g., metastatic colorectal cancer) in a subject in need thereof. The method includes suppressing the enzymatic activity of DHODH and/or decreasing the level of creatine via suppression of creatine transporter channel SLC6a8 in the subject. In some embodiments, the suppression step can be carried out by administering to the subject a set of small molecule compounds.
Claims32
A method for treating a metastatic gastrointestinal cancer in a subject in need thereof, the method comprising administering to the subject an effective amount of a dihydroorotate dehydrogenase (DHODH) inhibitor, or a pharmaceutically acceptable salt thereof, and an effective amount of a beta-guanidinopropionic acid (β-GPA), or a pharmaceutically acceptable salt thereof, to suppress metastatic colonization of gastrointestinal cancer.
A method for treating a gastrointestinal cancer in a subject in need thereof, comprising administering to the subject an effective amount of a DHODH inhibitor, or a pharmaceutically acceptable salt thereof, and β-GPA, or a pharmaceutically acceptable salt thereof in amounts which together are effective to suppress metastatic progression of the cancer.
Dependencies are inferred from the claim text.