Methods of treating disorders using CSFIR inhibitors
AssigneeDeciphera Pharmaceuticals, LLC
InventorsDaniel L. Flynn, Bryan D. Smith, Rodrigo Ruiz Soto, Keisuke Kuida
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Abstract
Described herein are methods of treating cancers and other tumors related to the decreased proliferation, the depletion, or the repolarization of tumor-associated macrophages (TAMs) and treatment of associated disorders, including tenosynovial giant cell tumor (TGCT) and diffuse-type tenosynovial giant cell tumor (DTGCT).
Claims29
A method of treating a tenosynovial giant cell tumor in a patient in need thereof, comprising administering to the patient a pharmaceutical composition comprising a compound represented by:
- and a pharmaceutically acceptable excipient, wherein the pharmaceutical composition is administered to the patient in an amount sufficient to provide the patient about 2 mg to about 60 mg of the compound once a day, twice daily, every other day, once a week, twice weekly, or three times a week.
A method of treating a tenosynovial giant cell tumor in a patient in need thereof, comprising administering to the patient a pharmaceutical composition comprising a compound represented by:
- and a pharmaceutically acceptable excipient, wherein the pharmaceutical composition is administered to the patient in an amount sufficient to provide the patient 30 mg of the compound twice weekly.
A method of treating a tenosynovial giant cell tumor in a patient in need thereof, comprising administering to the patient a pharmaceutical composition comprising a compound represented by:
- and a pharmaceutically acceptable excipient, wherein the pharmaceutical composition is administered to the patient in an amount sufficient to provide the patient a therapeutically effective amount of the compound.
Dependencies are inferred from the claim text.