Cyano-substituted pyridine and cyano-substituted pyrimidine compound and preparation method therefor and application thereof

A compound represented by formula (I), or a stereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof,

• in formula (I),
• X is N or CH;
• L is —O—, —S—,
• or —NR5—, wherein R5 and R6 are each independently hydrogen, methyl, ethyl, propyl or isopropyl;
• R1 is
• R2 is hydrogen, halogen, C1-C3 alkoxy, or C1-C3 alkyl;
• R3 is selected from hydrogen, halogen, hydroxyl, amino, cyano, carboxyl, C1-C6 alkyl, C1-C6 haloalkyl, C1-C3 haloalkoxy, C3-C6 cycloalkyl, C2-C3 alkynyl, C2-C3 alkenyl, C1-C3 alkoxy, C1-C3 alkylthio, mono- or di-C1-C3 alkylamino, C3-C4 cycloalkyloxy, C3-C4 cycloalkyl-substituted C1-C3 alkyl, cyano-substituted C1-C3 alkyl, carbamoyl-substituted C1-C3 alkyl, or the following groups:
• q is an integer of 1-3,
• Rs is selected from —H, or C1-C3 alkyl, and Rp is selected from —H, or C1-C3 alkyl,
• R′ and R″ are each independently —H, C1-C3 alkyl, or C3-C4 cycloalkyl,
• R7 is selected from —H, halogen, hydroxyl, cyano, amino, carboxyl, C1-C3 alkyl, C3-C4 cycloalkyl, C1-C3alkoxy, or mono- or di-C1-C3 alkyl-substituted amino;
• R4 is -T1-R8 or -T2-R9,
• T1 is:
• T2 is:
• p1 is an integer of 0-4, p2 is an integer of 2-4, and p3 is an integer of 0-1,
• Rp is —H or C1-C3 alkyl,
• R8 is selected from —H, halogen, hydroxyl, amino, cyano, C1-C6 alkyl, C1-C6 haloalkyl, C1-C3 haloalkoxy, C3-C6 cycloalkyl, C1-C3 alkoxy, C1-C3 alkylthio, mono- or di-C1-C3 alkylamino, or a 4- to 6-membered heteroalicyclic group, wherein the 4- to 6-membered heteroalicyclic group is unsubstituted or substituted with 1-2 identical or different substituents selected from hydroxyl, C1-C6 alkyl, C1-C3 alkoxy, formyl, acetyl, propionyl, isopropionyl, hydroxyl-substituted C1-C3 alkyl, carboxy-substituted C1-C3 alkyl, oxo, C1-C3 alkyl-substituted or unsubstituted 4- to 6-membered heteroalicyclic group, or —NR10R11,
• R10 and R11 are each independently selected from —H, C1-C6 alkyl, C3-C4 cycloalkyl, hydroxyl-substituted C2-C6 alkyl, cyano-substituted C1-C2 alkyl, C1-C3 alkoxy-substituted C1-C3 alkyl, C1-C3 alkylthio-substituted C1-C3 alkyl, C1-C3 haloalkyl, methylsulfonyl-substituted C1-C3 alkyl, mono- or di-C1-C3 alkylamino-substituted C1-C3 alkyl, or C1-C3 alkyl-substituted or unsubstituted 4- to 6-membered heteroalicyclic group, or R10 and R11 together with the nitrogen atom to which they are attached form a 4- to 6-membered heteroalicyclic group, wherein the 4- to 6-membered heteroalicyclic group is unsubstituted or substituted with 1-2 identical or different substituents selected from —H, hydroxyl, oxo, halogen, C1-C3 alkoxy-substituted C1-C3 alkyl, C1-C3 alkylsulfonyl, cyano, amino, C1-C3 acyl, C1-C3 alkyl, mono- or di-C1-C3 alkylamino, hydroxyl-substituted C2-C3 alkyl, or C1-C3 alkoxy,
• the 4- to 6-membered heteroalicyclic group contains 1-2 heteroatoms selected from N, O or S;
• R9 is selected from —H, C1-C6 alkyl, C3-C6 cycloalkyl, or a 4- to 6-membered heteroalicyclic group, wherein the 4- to 6-membered heteroalicyclic group is unsubstituted or substituted with 1-2 identical or different substituents selected from hydroxyl, C1-C3 alkyl, C1-C3 alkoxy, formyl, acetyl, propionyl, or isopropionyl,
• the 4- to 6-membered heteroalicyclic group in R9 contains 1-2 heteroatoms selected from N, O or S;
• and, when R1 is
• R4 is 4-ethyl-piperazin-1-yl, and L is —O— or
• R2 and R3 are not both hydrogen.