Compositions and methods for hair follicle regeneration
AssigneeWashington University
InventorHongzhen Hu
Life of this patent
Estimating the term…
Abstract
Among the various aspects of the present disclosure is the provision of compositions and methods for treating hair regeneration disorders or conditions such as hair loss or thinning. An aspect of the present disclosure provides for a method of treating hair loss, promoting hair growth, or treating hair loss, such as alopecia or telogen effluvium, comprising administering a TRPV4 activating agent to a subject.
Claims22
A method of treating hair loss or promoting hair growth comprising administering a therapeutically effective amount of a TRPV4 activating agent to a subject in need thereof, wherein the TRPV4 activating agent is selected from the group consisting of:
- RN 1747;
- 5,6-EET:
- Bisandrographolide A;
- Dimethylallyl pyrophosphate;
- and combinations thereof.
A method of inducing hair follicle regeneration comprising administering a TRPV4 activating agent to a subject in need thereof, wherein the TRPV4 activating agent is selected from the group consisting of:
- RN 1747;
- 5,6-EET;
- Bisandrographolide A;
- Dimethylallyl pyrophosphate;
- and combinations thereof.
A method of inducing telogen-anagen transition in a hair follicle cell comprising administering a therapeutically effective amount of a TRPV4 activating agent to a subject in need thereof, wherein the TRPV4 activating agent is selected from the group consisting of:
- RN 1747;
- 5,6-EET;
- Bisandrographolide A:
- Dimethylallyl pyrophosphate;
- and combinations thereof.
A method of increasing expression or upregulating an anagen-activating factor and decreasing expression of or downregulating an anagen-inhibiting factor in a cell comprising administering a TRPV4 activating agent to the cell, wherein the TRPV4 activating agent is selected from the group consisting of:
- RN 1747;
- 5,6-EET;
- Bisandrographolide A;
- Dimethylallyl pyrophosphate;
- and combinations thereof.
Dependencies are inferred from the claim text.