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US 12,582,637 B2Granted
Topical formulation for intradermal application and uses thereof
AssigneeArctic Therapeutics Hf
InventorsHakon Hakonarson, Charlly Kao, Edward T. Kisak, John M. Newsam, Avadhesh S. Kushwaha
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Abstract
The invention provides compositions comprising a topical formulation of donepezil and methods of use thereof for intradermal applications.
Claims20
A composition prepared for topical administration comprising
- (i) donepezil or a pharmaceutically acceptable salt thereof,
- (ii) 2-(2-ethoxyethoxy) ethan-1-ol,
- (iii) a fatty acid ester, and
- (iv) cetyl alcohol,
- wherein the composition is formulated to deliver donepezil intradermally.
2 more elements
A composition prepared for topical administration comprising:
- (i) donepezil or donepezil HCl;
- (ii) 2-(2-ethoxyethoxy) ethan-1-ol in an amount between about 5% (wt/wt) to about 30% (wt/wt);
- (iii) a fatty acid ester selected from the group consisting of isopropyl palmitate, caprylic triglyceride, capric (C10) triglyceride, isopropyl myristate, and any combination thereof in an amount between about 5% (wt/wt) to about 13% (wt/wt);
- and
- (iv) cetyl alcohol in an amount between about 3% (wt/wt) to about 11% (wt/wt);
- wherein the composition is formulated to deliver donepezil intradermally and wherein the composition is in a form of a cream.
3 more elements
Dependencies are inferred from the claim text.