Pharmaceutical composite formulation comprising proton pump inhibitor and antacid

A pharmaceutical composite formulation comprising:

• a first layer comprising a proton pump inhibitor or a pharmaceutically acceptable salt thereof as an active ingredient, a first disintegrant, and a binder;
• and
• a second layer comprising, as an active ingredient, an antacid selected from the group consisting of magnesium hydroxide, magnesium oxide, er and a mixture thereof, and a second disintegrant,
• wherein the proton pump inhibitor is esomeprazole or a pharmaceutically acceptable salt thereof,
• wherein the first disintegrant in the first layer is selected from the group consisting of crospovidone, sodium starch glycolate, and a mixture thereof,
• wherein an amount of the first disintegrant in the first layer is in a range of about 0.5 wt % to about 5.5 wt % based on a total weight of the first layer,
• wherein the second disintegrant in the second layer is selected from the group consisting of crospovidone, sodium starch glycolate, and a mixture thereof,
• wherein the binder is hydroxypropyl cellulose, and
• wherein an amount of the binder is in a range of about 1.5 parts to about 4.5 parts by weight based on 1 part by weight of the first disintegrant in the first layer.