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US 12,582,631 B2Granted
Methods of improving renal function
AssigneeChinook Therapeutics, Inc.
InventorsPhilip Thomas Frohlich, Andrew James King, Chidambaram Ramachandran, Sarah Beth Noonberg
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Abstract
Provided herein are methods of improving kidney function in a subject in need thereof.
Claims36
A method of causing a reduction in proteinuria in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of atrasentan, or a pharmaceutically acceptable salt thereof,
- wherein the subject has been previously diagnosed with IgA nephropathy and wherein the diagnosis of IgA nephropathy comprises a kidney biopsy, detecting anti-glycan antibodies, detecting deposition of IgA-immune complexes in the kidney, or a combination of any of the foregoing,
- wherein the subject has proteinuria of less than 1 g/day in at least two of three consecutive readings after initiation of administration of a therapeutically effective amount of atrasentan, or a pharmaceutically acceptable salt thereof, and
- wherein the IgA nephropathy is primary IgA nephropathy.
A method of causing a reduction in proteinuria in a subject in need thereof, comprising administering to the subject atrasentan at a once-daily dose of 0.75 mg, or an equivalent amount of a pharmaceutically acceptable salt thereof,
- wherein the subject has been previously diagnosed with IgA nephropathy and wherein the diagnosis of IgA nephropathy comprises a kidney biopsy, detecting anti-glycan antibodies, detecting deposition of IgA-immune complexes in the kidney, or a combination of any of the foregoing,
- wherein the subject has proteinuria of less than 1 g/day in at least two of three consecutive readings after initiation of administration of atrasentan, or a pharmaceutically acceptable salt thereof, and
- wherein the IgA nephropathy is primary IgA nephropathy.
Dependencies are inferred from the claim text.