Implantable medical devices for extended release of therapeutic agents
AssigneeNano Precision Medical, Inc.
InventorWouter Erik Roorda
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Abstract
The disclosure pertains to implantable medical devices for controlled delivery of therapeutic agents. Some devices according to the disclosure have a titanium reservoir, and a porous titanium oxide based membrane to control the rate of release of the therapeutic agent. The reservoir contains a formulation of the active agent, including a stabilizer for the active agent, wherein the stabilizer is provided in an extended-release configuration or a sustained release carrier.
Claims12
An implantable drug delivery system, said implantable drug delivery system comprising:
- a metal capsule suitable for implantation;
- a reservoir encapsulated by the capsule;
- at least one nanoporous membrane in fluid contact with the reservoir;
- wherein the reservoir contains a pharmaceutical composition including a water-soluble therapeutic agent with an equilibrium solubility at room temperature of more than 1.0×10−3 M;
- and
- at least one stabilizer, wherein said stabilizer is incorporated in a sustained release carrier.
A method for treating a disease in a subject in need thereof, the method comprising:
- administering an implantable drug delivery system, said implantable drug delivery system comprising:
- a metal capsule suitable for implantation;
- a reservoir encapsulated by the capsule;
- at least one nanoporous membrane in fluid contact with the reservoir;
- wherein the reservoir contains a pharmaceutical composition including a water soluble therapeutic agent with an equilibrium solubility at room temperature of more than 1.0×10−3 M;
- and
- at least one stabilizer, wherein said stabilizer is incorporated in a sustained release carrier.
Dependencies are inferred from the claim text.