Heart valve replacement prosthesis with variable sealing function

A heart valve prosthesis comprising:

• a frame,
• a replacement valve and
• a sealing means;
• wherein the prosthesis has a first end and a second end and the first and second ends of the prosthesis form a conduit and wherein valve leaflets open when a fluid enters into the first end to allow the fluid to flow through the conduit in a forward direction and the valve closes when a fluid flows into the second end to prevent the fluid to flow through the conduit in a reverse direction, wherein flow through the conduit in the forward direction is a forward valve flow, characterized by an initial defined amount of a blood backwards flow in the reverse direction of about 5 to about 40 percent of the forward valve flow when the valve leaflets are closed;
• wherein the heart valve prothesis is configured so that the amount of blood backward flow in the reverse direction decreases over a defined time frame of 1 to 90 days.