Gold particles and uses thereof
AssigneeElux Medical, Inc.
InventorsRobert Kelly Moore, Jordan Sebastian Warburg
Life of this patent
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Abstract
The present disclosure in various aspects and embodiments provides, inter alia, systems and methods for minimally-invasive lipolysis in a target area by injecting the area with a solution of photo-absorbing nanoparticles and irradiating the injected area with a beam of near infrared (NIR) light. The NIR emission wavelength may in certain embodiments be adapted to excite the nanoparticles to melt fat within the target area; in some embodiments so that the liquefied fat can be aspirated from the target area, or in some embodiments such that aspiration of the liquified fat is not needed. In certain aspects and embodiments the nanoparticles are be gold nanoshells; for example, spherical gold nanoshells.
Claims17
A method for localized thermal ablation of adipose tissue in a subject, comprising:
- locally administering a solution comprising a plurality of nanoshells that absorb light at near infrared (NIR) wavelengths by subcutaneous injection of the solution into one or more locations within a target adipose tissue of the subject, thereby delivering the nanoshells immediately adjacent to the point of administration within the target adipose tissue, wherein the solution comprises the plurality of nanoshells at a concentration between 1.0×109 and 1.0×1011 particles per mL, wherein the nanoshells comprise an overall diameter of between 150-170 nm, a gold outer shell of between 15 and 25 nm thickness that converts absorbed NIR light into heat via surface plasmon resonance, and a silicon dielectric core, and wherein cetyltrimethylammonium bromide (CTAB) is not used in the manufacture of the nanoshells;
- and
- delivering NIR light across an area of skin overlying the target adipose tissue to induce surface plasmon resonance from the injected nanoshells, thereby causing localized thermal ablation within the target adipose tissue, wherein the localized thermal ablation is melting of fat within the target adipose tissue.
A method for localized thermal ablation of adipose tissue in a subject, comprising:
- locally administering a solution comprising a plurality of nanoshells that absorb light at near infrared (NIR) wavelengths by subcutaneous injection of the solution into one or more locations within a target adipose tissue of the subject, thereby delivering the nanoshells immediately adjacent to the point of administration within the target adipose tissue, wherein the solution comprises the plurality of nanoshells at a concentration between 1.0×109 and 1.0×1011 particles per mL, wherein the nanoshells comprise an overall diameter of between 150-170 nm, a gold outer shell of between 15 and 25 nm thickness that converts absorbed NIR light into heat via surface plasmon resonance, and a silicon dielectric core;
- and
- delivering NIR light across an area of skin overlying the target adipose tissue to induce surface plasmon resonance from the injected nanoshells, thereby causing localized thermal ablation within the target adipose tissue, wherein the localized thermal ablation is melting of fat within the target adipose tissue, wherein the method does not comprise aspirating liquid having subcutaneous tissue and/or liquefied fat from the target adipose tissue after the subcutaneous injection of the nanoshells and the delivery of NIR light.
Dependencies are inferred from the claim text.