Ultrasound based three-dimensional lesion verification within a vasculature

An ultrasound imaging system comprising a console that is configured to be operably associated with an imaging device, wherein the console comprises a processor configured to:

• receive, in real-time, full circumferential, three-dimensional (3D) image data from the catheter-based ultrasound imaging device operating in both an ultrafast planewave imaging acquisition mode and an ultrafast diverging imaging acquisition mode, the image data comprising associated reflected signal data;
• process the reflected signal data using a compounding algorithm, the reflected signal data comprising planewave data and diverging wave data;
• and
• reconstruct, in real-time, a 3D image providing a 360-degree visualization of intravascular tissue from said 3D image data, wherein the 3D image visually depicts one or more lesion formations in a targeted portion of the intravascular tissue, including a pathway of the one or more lesion formations and a depth of the one or more lesion formations, wherein the 3D image further depicts any discontinuities present in one or more ablations cooperatively forming the one or more lesion formations, including one or more physical gaps between two or more ablations and one or more physical gaps present within a depth of the one or more ablations, wherein visual depictions provided via the 3D image comprise at least one of slice-based and volume-based images of the targeted portion of the intravascular tissue illustrating anatomical depictions of the intravascular tissue;
• wherein a rate of reconstruction of the 3D image is the same as, and concurrent with, a rate of receipt of the full circumferential, 3D image data and reconstruction of the 3D image, including visual depiction of the one or more lesion formations, is based, at least in part, on registration of 3D image data representative of lesion formation identified in the intravascular tissue with histopathological data representative of ground truth tissue microstructure of the intravascular tissue, wherein said 3D image data comprises lesion maps reconstructed in 3D and said histopathological data comprises a series of histopathological two-dimensional (2D) images reconstructed into a labeled 3D volume.