Method and system to assess pulmonary hypertension using phase space tomography and machine learning

A system comprising:

• a processor;
• and
• a memory having instructions stored thereon, wherein the instructions when executed by the processor cause the system to:
• obtain acquired data from a measurement of one more biophysical signals of a subject, wherein the acquired data is derived from measurements acquired via noninvasive equipment configured to measure properties of a heart;
• generate a phase space data set from the acquired data;
• perform a residue topology analysis on the phase space data set to generate one or more metrics;
• generate, using a machine learning algorithm, one or more predictors linking aspects of the one or more metrics across a population of patients representing both positive and negative cases to detect the presence of pulmonary hypertension;
• and
• output, via one or more of an output data set, the one or more predictors, wherein the output is subsequently used for an assessment of presence and/or non-presence of pulmonary hypertension.

A non-transitory computer readable medium having instructions stored thereon, wherein execution of the instructions by a processor, cause the processor to:

• obtain acquired data from a measurement of one more biophysical signals of a subject, wherein the acquired data is derived from measurements acquired via noninvasive equipment configured to measure properties of a heart;
• generate a phase space data set from the acquired data;
• perform a residue topology analysis on the phase space data set to generate one or more metrics;
• generate, using a machine learning algorithm, one or more predictors linking aspects of the one or more metrics across a population of patients representing both positive and negative cases to detect the presence of pulmonary hypertension;
• and
• output, via one or more of an output data set, the one or more predictors, wherein the output is subsequently used for an assessment of presence and/or non-presence of pulmonary hypertension.