Analyte sensor devices, connections, and methods

An assembly comprising:

• an applicator, comprising a sharp;
• an on-body device, comprising:
• (1) a glucose sensor, comprising:
• a proximal portion configured to electrically couple with a printed circuit board;
• and
• a distal portion configured to be positioned under a skin surface and in contact with a bodily fluid of a subject;
• (2) a housing, comprising:
• a top portion comprising a top exterior surface and a first aperture;
• a base portion configured to be adhered to the skin surface of the subject by an adhesive patch;
• and
• an enclosure defined by the top portion and the base portion;
• and
• (3) sensor electronics positioned within the enclosure, the sensor electronics comprising a processor, a battery, and the printed circuit board, wherein the printed circuit board comprises a second aperture,
• wherein the base portion of the housing comprises a recess in a bottom exterior surface, the recess comprising a distal-facing opening, and wherein the recess is configured to receive the proximal portion of the glucose sensor via the distal-facing opening,
• wherein the housing further comprises a plurality of engagement recesses circumferentially disposed thereon, and wherein the engagement recesses are configured to be detachably engaged with the applicator,
• wherein the proximal portion of the glucose sensor is disposed in the recess such that the glucose sensor is electrically coupled with the sensor electronics,
• wherein the applicator is configured to advance the on-body device and the sharp from a first position to a second position such that a distal end of the sharp pierces the skin surface of the subject and the base portion of the housing is adhered to the skin surface of the subject,
• wherein the on-body device and the sharp are entirely disposed within an interior of the applicator when the on-body device and the sharp are in the first position,
• wherein the sharp extends through the first aperture of the top portion of the housing and the second aperture of the printed circuit board when the on-body device and the sharp are in the first position, and
• wherein the applicator is further configured to automatically retract the distal end of the sharp from within the subject to within the interior of the applicator.